DIASTEREOFACE-DIFERENTIATING ADDITION OF ORGANOMETALLICS TOWARD CHIRAL α-KETOENAMINES

Article abstract of DOI:10.1246/cl.1984.2055

The diastereoface-differentiating reaction of Grignard reagents or organolithium reagents toward chiral cyclic α-ketoenamines, prepared from the corresponding cycloalkane-1,2-dione and optically active pyrrolidine derivatives, was found to give, after hydrolysis, (R)- or (S)-α-hydroxycycloalkanones, respectively, in high enantiomeric excess.