Synthesis and biological activities of two ACTH analogues containing L norarginine in position 8

Article abstract of DOI:10.1111/j.1399-3011.1977.tb03481.x

2 new ACTH-analogues, an octadecapetide amide and a tetracosapeptide containing the lower homologue of arginine (norarginine) in position 8, have been synthesized by the generally accepted method. Special attention was paid to the synthesis of the required tetrapeptide representing the 7-10 sequence, which was obtained either by direct introduction of L-nitronorarginine or by amidination of the γ-amino function in a protected peptide containing α, γ diaminobutyric acid. Biological activity determination showed that the shortening of the arginine side chain in position 8 results in the formation of active ACTH-analogues.