Synthetic carbapenem antibiotics II. Stereoisomers of 7-hydroxyethyl-2,2,5-trimethyl-3-oxa-1-azabicyclo[4.2.0]-octan-8-one

Article abstract of DOI:10.1016/S0040-4039(00)89153-4

The titled compounds are key synthetic intermediates in the structure-activity relationship studies of novel 1-methyl carbapenem antibiotics. Preparation and structural determination of these stereoisomers by X-ray crystallography and proton NMR spectroscopy are reported.