Journal of Organic Chemistry p. 3767 - 3774 (1985)
Update date:2022-07-29
Topics:
Dauben, William G.
Saugier, R. Kent
Fleischhauer, Ilona
A stereospecific synthesis of the basic crassin acetate nucleus, erythro-1-(hydroxymethyl)-14-hydroxy-4,8,12-trimethylcyclotetradeca-(E,E,E)-3,7,11-triene, has been achieved.Stereospecific syntheses of the two precursors to this ring system, (E,E)-3,7-dimethyl-9-(phenylthio)nona-3,7-dienal and (E)-2,8-bis(trimethylsiloxy)-2,7-dimethyloct-6-en-3-one, have been developed.These moieties were combined via an aldol condensation to yield erythro-9-hydroxy-10-<1-oxo-2-methyl-2-(trimethylsiloxy)propyl>-1-(phenylthio)-14-(trimethylsiloxy)-3,7,13-trimethyltetradeca-(E,E,E)-2,6,12-triene which, in a series of reactions, was cyclized to the titled 14-membered ring system.
View Morewebsite:https://www.synose.com/
Contact:86-579-82275537
Address:No.1958 Liyu Road , jinhua,zhejiang,China
website:http://www.sjc.com.tw
Contact:(886) 2-2396-6223
Address:14Fl., No. 99. Sec. 2, Jen Ai Road
Zhejiang Haizhou Pharmaceutical Co., Ltd.
website:https://www.haizhoupharma.com/
Contact:+86-576-88221016
Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Contact:+852-8198 2399
Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Hangzhou Maytime Bio-Tech Co.,Ltd.
website:http://www.maytime.com.cn
Contact:+86-571-88925295 88920965
Address:NO.2-1701 Ganghui Central Ningwei Street, Xiaoshan Hangzhou Zhejiang China
Doi:10.1016/S0040-4020(01)96402-6
(1985)Doi:10.1016/S0040-4039(00)81807-9
(1983)Doi:10.1016/j.bmcl.2007.01.098
(2007)Doi:10.1039/c4ra03865g
(2014)Doi:10.1016/j.poly.2005.07.019
(2006)Doi:10.1021/jo9015858
(2009)
