Synthesis and antiherpes simplex virus activity of 9-[(1,3-dihydroxy-2-propylthio)methyl]guanine

DOI: 10.1021/jm00147a020

Source and publish data:

Journal of Medicinal Chemistry p. 1242 - 1245 (1985)

Update date:2022-08-05

Topics:

Authors:

McGee McGee

Martin Martin

Smee Smee

Matthews

Verheyden

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Article abstract of DOI:10.1021/jm00147a020

The synthesis of the thio analogue (thio-DHPG, 2) of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG) is described. The synthesis of 2 proceeded via the condensation of acetoxymethyl sulfide with diacetylguanine to give the protected nucleoside analogue

Full text of DOI:10.1021/jm00147a020

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