Leukotriene Receptor Antagonists. 2. The methyl>acetophenone Derivatives

DOI: 10.1021/jm00388a028

Source and publish data:

Journal of Medicinal Chemistry p. 911 - 918 (1987)

Update date:2022-08-02

Topics:

Authors:

Dillard, Robert D.

Carr, F. Patrick

McCullough, Doris

Haisch, Klaus D.

Rinkema, Lynn E.

Fleisch, Jerome H.

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Article abstract of DOI:10.1021/jm00388a028

A series of <<(tetrazol-5-ylaryl)oxy>methyl>acetophenones was synthesized and evaluated as antagonists of leukotriene D₄ induced contractions of guinea pig ileum.Substitution at the 3-position of the acetophenone with ethyl (66), propyl (68), b

Full text of DOI:10.1021/jm00388a028

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