A new, efficient, two step procedure for the preparation of the antineoplastic agent sparfosic acid

Article abstract of DOI:10.1080/00397919708003363

Sparfosic acid can easily be prepared in two steps and in excellent yield from condensation of the commercially available starting materials L-aspartic acid di-tert-butyl ester hydrochloride and diethylphosphonoacetic acid, followed by a quadruple deprotection of acidic functions under mild conditions using bromotrimethylsilane.

Full text of DOI:10.1080/00397919708003363

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A New, Efficient, Two Step
Procedure for the Preparation
of the Antineoplastic Agent
Sparfosic Acid
Angela D. Morris a & Alex A. Cordi a
a Institut de Recherches Servier , 11 rue des
Moulineaux, 92150, Suresnes, France
Published online: 22 Aug 2006.
To cite this article: Angela D. Morris & Alex A. Cordi (1997) A New, Efficient, Two
Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 27:7, 1259-1266, DOI: 10.1080/00397919708003363
To link to this article: http://dx.doi.org/10.1080/00397919708003363
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