Journal of Organic Chemistry p. 5765 - 5770 (1993)
Update date:2022-07-30
Topics:
Marques, C. A.
Selva, M.
Tundo, P.
Montanari, F.
The reaction of ketone oximes with dimethyl carbonate (DMC) carried out in an autoclave at 180-190 deg C and in the presence of K2CO3 yields 3-methyl-4,5-disubstituted-4-oxazolin-2-ones.The reaction can be applied to both aliphatic and aromatic ketone oximes, provided that a methylene group be present near the C=N bond.Nonoptimized yields range from 22 to 48percent.The reaction seems to be a <3,3> sigmatropic rearrangement where DMC plays a key role in causing the initial N-methylation of the oximes.
View MoreChangzhou Yongxu Chemical Co.,Ltd
Contact:86-0519-85286591
Address:Room 1812,Wanda Plaza B,Xinbei District,Changzhou,Jiangsu,China
shanghai Tauto Biotech Co., Ltd
website:http://www.tautobiotech.com/en/index.htm
Contact:+86-21-51320588 ext. 8025
Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
SuZhou Bichal Biological Technology CO.,LTD
Contact:+86-512-68051130
Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
Qingdao Xinnuo pharmaceutical Chemical Co.,Ltd
Contact:86-186-15688656
Address:50 Meters North To YuanHou Community Committee,Xifuzhen Subdistrict,Chengyang District,Qingdao
website:http://www.antaibio.com
Contact:86-21-60939051,60939771
Address:Room 2108, Building 2,No. 489 Zhengli Road,200433
Doi:10.1139/v97-149
(1997)Doi:10.1016/j.tet.2007.03.113
(2007)Doi:10.1039/c8cc01499j
(2018)Doi:10.1021/om1000265
(2010)Doi:10.1002/adsc.200900778
(2010)Doi:10.1016/j.bmc.2010.01.028
(2010)