Journal of the Chemical Society. Chemical communications p. 1021 - 1022 (1985)
Update date:2022-08-04
Topics:
Patel, Premji
Joule, John A.
Lithiation of 1-methyl-4-pyridone with n-butyl-lithium at -78 deg C proceeds smoothly at the C-2 position and 2-substituted-4-pyridones (1c-j) are obtained by subsequent reaction with electrophiles; lithiation of 1-methyl-2-pyridone takes place predominantly at the N-methyl, the lithio-derivative reacting rapidly, even at -78 deg C with starting pyridone to give a dimer, (3).
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