Electrochemical oxidation of benzyl chlorides: A new synthesis of 5-methyl-2-pyrazinecarboxylic acid

Article abstract of DOI:10.1055/s-1990-26830

A new high yield and selective electrochemical oxidation of benzyl chlorides to the corresponding aromatic acids at the nickel hydroxide electrode is reported. The utility of this method is exemplified by the new synthesis of 5-methyl-2-pyrazinecarboxylic acid, an important pharmaceutical intermediate.