Organic Process Research and Development p. 2549 - 2555 (2019)
Update date:2022-08-11
Topics:
Carroll, Michael P.
Moloney, Harold
Gowran, Olivia
O'Connor, Aoibheann
Wilson, Eoin M.
Murray, Michael M.
Pietz, Mark A.
Kjell, Douglas P.
Held, C. Brad
Frederick, Michael O.
A new synthesis for an intermediate of abemaciclib is described. Keys to this route are the use of inexpensive starting materials, biphasic amine alkylation for mild C-N bond formation, anhydrous coupling of a 2-chloropyridine derivative with LiHMDS to avoid a hydroxy impurity, and neutral, fluoride-free conditions to affect desilylation. Scale-up of the optimized conditions are described on a kilogram scale.
View MoreZhejiang Hoshine Silicon Industry Co., Ltd.
Contact:86-573-89179966
Address:Zhapu Town, Pinghu City, Zhejiang, China
website:http://www.biet.com.cn/
Contact:+86-27-8369 8488
Address:No. 6, Building 21, China Merchants Fanwang, Sixin North Road, Hanyang District, Wuhan City, Hubei Province
website:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Wuhan Fortuna Chemical Co.,Ltd
website:http://www.fortunachem.com
Contact:86-27-59207852
Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Taizhou Chemedir Biopharm-tech Co., Ltd
Contact:+86 523 86200218
Address:G09, No. 1 Avenue China Medical City, Taizhou,Jiangsu, China
Doi:10.1021/acs.inorgchem.7b00771
(2017)Doi:10.1007/BF00952189
(1981)Doi:10.1039/c9gc00166b
(2019)Doi:10.1002/cctc.201301107
(2014)Doi:10.1016/j.tetlet.2010.11.022
(2011)Doi:10.1002/chem.201905133
(2020)