Synthesis p. 1127 - 1128 (1994)
Update date:2022-08-29
Topics:
Correia
A hypochlorite liquid triphasic system prepared from aqueous sodium hypochlorite, sodium bromide, and tetrabutylammonium hydrogen sulfate was found to be effective in converting primary, substituted acetamides to nitriles with loss of one carbon via the Hofmann rearrangement in yields of 48-68%.
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