A mild and efficient method for tetrahydropyranylation/depyranylation of alcohols and phenols under neutral conditions

Article abstract of DOI:10.1080/00397910008087055

Alcohols and phenols are tetrahydropyranylated rapidly in high yields in the presence of lithium bromide and dichloromethane at room temperature. Deprotection of these THP ethers can also be effected readily by mere change of the solvent to methanol and refluxing with excess lithium bromide. Due to neutral reaction conditions employed, the method is also compatible with compounds having acid sensitive functional groups.

Full text of DOI:10.1080/00397910008087055

This article was downloaded by: [Michigan State University]
On: 29 December 2014, At: 22:39
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Mild and Efficient Method
for Tetrahydropyranylation/
Depyranylation of Alcohols
and Phenols Under Neutral
Conditions
M. Arjun Reddy a , L. Rajender Reddy a , N.
Bhanumathi a & K. Rama Rao a
a Organic Chemistry-I , Indian Institute of Chemical
Technology , Hyderabad, 500 007, India
Published online: 04 Dec 2007.
To cite this article: M. Arjun Reddy , L. Rajender Reddy , N. Bhanumathi & K. Rama
Rao (2000) A Mild and Efficient Method for Tetrahydropyranylation/Depyranylation
of Alcohols and Phenols Under Neutral Conditions, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 30:23,
4323-4328, DOI: 10.1080/00397910008087055
To link to this article: http://dx.doi.org/10.1080/00397910008087055
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views

expressed in this publication are the opinions and views of the authors, and
are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with
primary sources of information. Taylor and Francis shall not be liable for any
losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or
indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions