The Cyanation of Aromatic Halides Catalyzed by Nickel(0) Complexes Generated in Situ. II. The Cyanation of Heteroaromatic Halides

Article abstract of DOI:10.1246/bcsj.66.2776

The cyanation of 3-bromopyridine catalyzed by in situ generated Ni(PPh3)n was examined with various MCN (M = K, Na)-dipolar aprotic solvent systems by four procedures.Under certain reaction conditions, 3-bromopyridine and several heteroaromatic halides were cyanated to give the corresponding nitriles in fair to good yields.Noticeable differences in reactivity among 3-bromopyridine, 3-bromofuran, 3-bromothiophene, and bromobenzene were observed.