Journal of Organic Chemistry p. 4444 - 4448 (1995)
Update date:2022-08-29
Topics:
Xi, Zhenfeng
Hara, Ryuichiro
Takahashi, Tamotsu
Highly selective alkyne-alkyne cross coupling reactions were achieved using Cp2ZrBu2 and ethylene gas.First, alkynes were treated with 1.2 equiv of Cp2ZrBu2 (Negishi reagent) under ethylene gas to give zirconacyclopentenes with high selectivities.Subsequent addition of a second alkyne to the solution of zirconacyclopentenes at 50 deg C gave unsymmetrical zirconacyclopentadienes selectively.After hydrolysis unsymmetrical dienes were obtained in high yields.
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