Lipase Catalyzed Resolution of 1-t-Butylthio-2-alkanols: Enzyme Mediated Routes to Enantiomerically Pure 1,2-Epoxyalkanes and 2-Alkanols

Article abstract of DOI:10.1016/S0957-4166(00)82099-6

A series of 1-t-butylthio-2-alkanols (R)- and (S)-1-5 were prepared via lipase catalyzed resolution of the corresponding chloroacetates (+/-)-1a-5a and further converted into the optically pure alkyloxiranes (R)-6-8 and 2-alkanols (R)-14-15