Tetraethylene glycol-derived spacer for oligonucleotide synthesis

Article abstract of DOI:10.1080/07328319908044669

3,6,9-Trioxaundecane-1,11-diisocyanate (6) was synthesised from tetraethylene glycol in 5 steps and 48 % overall yield. Spacer 6 was monofunctionalised with the fully protected adenosyl-3'-O-succinate derivative 7 and linked to aminomethyl polystyrene affording a solid support suitable for oligoribonucleotide synthesis (loading: ~20 μmol/g). The HPLC analysis of a crude oligoribonucleotide synthesis and the yield of the full- length product show that this spacer compares well to hexamethylene diamine.

Full text of DOI:10.1080/07328319908044669

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Nucleosides and Nucleotides
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Tetraethylene Glycol-Derived Spacer for
Oligonucleotide Synthesis
Sigmund Gunzenhauser a , Ewa Biala a & Peter Strazewski a
a Institute of Organic Chemistry, University of Basel , St. Johanns-
Ring 19, CH, 4056, Basel, Switzerland
Published online: 04 Oct 2006.
To cite this article: Sigmund Gunzenhauser , Ewa Biala & Peter Strazewski (1999) Tetraethylene
Glycol-Derived Spacer for Oligonucleotide Synthesis, Nucleosides and Nucleotides, 18:6-7, 1223-1224,
DOI: 10.1080/07328319908044669
To link to this article: http://dx.doi.org/10.1080/07328319908044669
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