Bioorganic and Medicinal Chemistry Letters p. 3473 - 3476 (2004)
Update date:2022-08-11
Topics:
Santos, Webster L.
Heasley, Brian H.
Jarosz, Renata
Carter, Karen M.
Lynch, Kevin R.
Macdonald, Timothy L.
Using an N-oleoyl ethanolamide scaffold, a series of phosphate polar head group analogues of LPA comprised of various α-substituted phosphonates and thiophosphates was prepared. In a broken cell GTP[γ35S] binding assay, agonist activity was evaluated at the three LPA receptors of the endothelial differentiation gene (Edg) family. This study has resulted in the discovery of a nonhydrolyzable LPA1-selective agonist (11). Additionally, thiophosphate 19 bears an isosteric phosphate mimetic that confers agonism at the LPA1 receptor but not LPA2.
View MoreChengdu Green technology Co.,Ltd.
Contact:86-28-82608355
Address:C9 ,Economic Headquarters, Economic Development Zone, Chengdu.
Nanjing lanbai chemical Co.,Ltd.
Contact:+86-25-85499326
Address:Room 908, 9F Taiyue Building,No.285 Heyan Road
SuZhou Bichal Biological Technology CO.,LTD
Contact:+86-512-68051130
Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
Shanghai Mio Chemical Co., Ltd
Contact:0086 21- 64401188-622
Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
Wuhan Chemwish Technology Co., Ltd
website:http://www.chemwish.com/
Contact:+86-27-67849912
Address:Room 1311, Unit 2, Block1, Innovation Road East Lake High-tech Development Zone Wuhan, Hubei,P.R. China
Doi:10.1246/cl.2000.614
(2000)Doi:10.1016/S0040-4020(00)01039-5
(2001)Doi:10.1039/d0pp00140f
(2020)Doi:10.1016/j.jfluchem.2018.11.009
(2019)Doi:10.1246/cl.2005.1060
(2005)Doi:10.1021/ja00771a060
(1972)