A new P-chiral bisphosphine, (S,S)-1,2-bis[(o-ethylphenyl)phenylphosphino]ethane, as an effective ligand in catalytic asymmetric hydrogenation of α-(acylamino)acrylic acids

Article abstract of DOI:10.1016/0040-4039(95)01775-D

(S,S)-1,2-Bis[(o-ethylphenyl)phenylphosphino]ethane has been prepared via optically active phosphine-boranes. Asymmetric hydrogenation of α-(acylamino)acrylic acids by a rhodium complex with this ligand affords N-acylamino acids in 86-93% ee.