Preparation of potential anti-inflammatory agents from dehydroabietic acid

Article abstract of DOI:10.1002/jps.2600810711

Methyl 16-nor-16-carboxydehydroabietate (22), 16-nor-16- carboxydehydroabietinol acetate (23), methyl 7-keto-16-nor-16- carboxydehydroabietate (29), 16-nor-16-carboxydehydroabietic acid (30), 16- nor-16-carboxydehydroabietinol (31), 7-keto-16-nor-16-carboxydehydroabietic acid (32), methyl 7-hydroxy-16-nor-16-carboxydehydroabietate (33), and 7- hydroxy-16-nor-16-carboxydehydroabietic acid (34) were prepared from dehydroabietic acid. Only 22 and 32 had weak anti-inflammatory activity.