A practical method for the preparation of α'-chloroketones of N-carbanaate protected-α-aminoacids

Article abstract of DOI:10.1016/S0040-4039(97)00605-9

A practical method for the preparation of α-N-BOC-epoxides from protected amino acid esters based on the Kowalski homologation reaction is described. This procedure can be readily performed on a large scale without the use of hazardous reagents and has allowed preparation of epoxides 3 in multi-kilogram quantities.