Highly stereoselective preparation of α-glucosides utilizing anomerization reaction with MgBr2·OEt2 and a catalytic amount of titanium(IV)tetrahalides

Article abstract of DOI:10.1246/cl.1997.625

The anomerization reactions of several β-D-glucopyranosides proceed smoothly in the coexistence of MgBr₂·OEt₂ and a catalytic amount of titanium(IV)halides to afford the corresponding α-D-glucopyranosides. The desired alkyl α-glucosides and α-anomer of disaccharides such as Glcα1-6Glc were obtained in high yields with high stereoselectivities.