Practical Method for the Synthesis and Optical Resolution of Axially Dissymmetric 6,6'-Dimethylbiphenyl-2,2'-dicarboxylic Acid

Article abstract of DOI:10.1246/bcsj.60.3659

Racemic 6,6'-dimethylbiphenyl-2,2'-dicarboxylic acid (1) could be conveniently synthesized and efficiently resolved by the recrystallization of the brucine salts in satisfactory yields.Each enantiomer, thus obtained, was confirmed to be optically pure from a high-performance liquid chromatographic (HPLC) analysis on an optically active column.