Stereoselective catalytic Tishchenko reduction of β-hydroxyketones using scandium triflate

Article abstract of DOI:10.1016/S0040-4039(99)01986-3

A number of aliphatic and aromatic β-hydroxyketones were reduced to 1,3-diol monoesters by aldehydes in the presence of a catalytic amount of scandium triflate. Chiral substrates were reduced with high 1,3-anti diastereoselectivity.