A convenient synthesis of substituted 3-pyrrolin-2-ones from α-cetols

Article abstract of DOI:10.1080/00397919308013792

A simple and efficient method for the preparation of the title compounds is described from cyanoacetamides and 3-hydroxy-3-methyl-2-butanone in the presence of sodium ethylate at room temperature. The 3-carboxamido-N-alkyl-4,5,5-trimethyl-5-dihydro-2H-pyrrol-2-ones lead to unsaturated derivatives by condensation with aldehydes, while hydrogenation give rise to the corresponding pyrrolidin-2-ones.

Full text of DOI:10.1080/00397919308013792

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Synthetic Communications: An
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Organic Chemistry
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A Convenient Synthesis Of
Substituted 3-Pyrrolin-2-ones
from α-Cetols
a
a
Gaguik Melikian , Francis Rouessac & Christian
a
Alexandre
a
Laboratoire de Synthese Organique, associé au
CNRS, URA 482 Faculté des Sciences , Avenue O.
Messiaen, BP 535, F-72017, Le Mans
Published online: 23 Sep 2006.
To cite this article: Gaguik Melikian , Francis Rouessac & Christian Alexandre (1993)
A Convenient Synthesis Of Substituted 3-Pyrrolin-2-ones from α-Cetols, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 23:19, 2631-2638, DOI: 10.1080/00397919308013792
To link to this article: http://dx.doi.org/10.1080/00397919308013792
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