Fluorine at the C5 Position of 2′-Deoxyuridine Enhances Repair of a O4-Methyl Adduct by O6-Alkylguanine DNA Alkyltransferases

DOI: 10.1002/ejoc.201700466

Source and publish data:

European Journal of Organic Chemistry p. 3003 - 3008 (2017)

Update date:2022-08-11

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Authors:

Sacre, Lauralicia

Wilds, Christopher J.

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Article abstract of DOI:10.1002/ejoc.201700466

Alkylation damage at the O⁶- and O⁴-atoms of 2′-deoxyguanosine (dG) and thymidine (T), respectively, can be removed by O⁶-alkylguanine-DNA alkyltransferases (AGTs). Previous studies have shown that human AGT (hAGT) repairs

Full text of DOI:10.1002/ejoc.201700466

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