Amine and thiazole substituted γ-butyrolactones from naturally occurring limonene

Article abstract of DOI:10.1139/v11-016

Substituted γ-butyrolactones are important structural motifs in several natural products and pharmaceuticals. In this paper, we report the synthesis of novel γ-butyrolactone amine and thiazole derivatives from naturally occurring limonene. Regioselective bromination followed by nucleophilic substitution with different amines and thiourea gave desired products in moderate yield.

Full text of DOI:10.1139/v11-016

639
Amine and thiazole substituted γ-butyrolactones
from naturally occurring limonene
Pushpinder Kaur, Pralay Das, Abha Chaudhary, and Bikram Singh
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Kaur et al.
641
Table 1.
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642
Can. J. Chem. Vol. 89, 2011
1
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643
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References
(
1
8
.
A
d
v
a
n
c
e
d
O
r
g
a
n
i
c
C
h
e
m
i
s
t
r
y
:
R
e
a
c
t
i
o
n
s
,
M
e
c
h
a
n
-
(
1
)
(
a
)
Y
o
k
o
m
a
t
s
u
,
T
.
;
Y
u
a
s
a
,
Y
.
;
K
a
n
o
,
S
.
;
S
h
i
b
u
y
a
,
S
.
isms and Structure, 4 t h e d . ; W i l ey : N ew Yo r k , 2 0 0 3 ; p 5 8 8 .
P
u
b
l
i
s
h
e
d
b
y
N
R
C
R
e
s
e
a
r
c
h
P
r
e
s
s