Stereoselective reduction of α- and β-keto esters with aerobic thermophiles, Bacillus strains

Article abstract of DOI:10.1271/bbb.60.1896

The first example of stereoselective reduction with aerobic thermophiles is reported. Various α- and β-keto esters were reduced stereoselectively to the corresponding alcohols by the aerobic thermophiles, Bacillus strains. In particular, the reduction of ethyl 3-methyl-2-oxobutanoate with B. stearothermophilus DSM 297 gave the corresponding (R)-alcohol with high yield in excellent enantioselectively (> 99% e.e.). The conversions of keto esters to the corresponding hydroxy esters with Bacillus strains were increased by introduction of glycerol in the reaction mixture as an additive.

Full text of DOI:10.1271/bbb.60.1896

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Stereoselective Reduction of α- and β-Keto Esters
with Aerobic Thermophiles, Bacillus Strains
Kohji Ishiharaa, Keisuke Iwaia, Hitomi Yamaguchia, Nobuyoshi Nakajimaab, Kaoru
Nakamuraac & Toshihisa Ohshimaa
a Department of Chemistry, Kyoto University of Education, Fushimi-ku, Fukakusa, Kyoto
612, Japan
b Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama
719–11, Japan
c Institute for Chemical Research, Kyoto University, Uji, Kyoto 611, Japan
Published online: 12 Jun 2014.
To cite this article: Kohji Ishihara, Keisuke Iwai, Hitomi Yamaguchi, Nobuyoshi Nakajima, Kaoru Nakamura & Toshihisa
Ohshima (1996) Stereoselective Reduction of α- and β-Keto Esters with Aerobic Thermophiles, Bacillus Strains, Bioscience,
Biotechnology, and Biochemistry, 60:11, 1896-1898, DOI: 10.1271/bbb.60.1896
To link to this article: http://dx.doi.org/10.1271/bbb.60.1896
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