On the mode of baker's yeast reduction of C-7 - C-10 2-alken-4-olides

Article abstract of DOI:10.1016/0040-4039(93)85072-5

Baker's yeast reduction of lactones 8, a-d proceeds under kinetic resolution to give (S) 11, a-d of low ee values, increasing with the length of the side chain, occurring the double bond saturation in anti fashion on the beta re face, as indicated by the obtainment from 4 and 6 of 5 and 7, respectively.