Tetrahedron p. 2961 - 2965 (1980)
Update date:2022-08-16
Topics:
Titouani, S.Lafquih
Lavergne
Viallefont
Jacquier
The Hofmann-Loeffler-Freytag reaction, carried out by irradiation in sulphuric acid of N-chloro-l-amino-acids 3a-d, gives δ-chlorinated compounds which can be cyclized to l-prolines 4a-e. This convenient synthesis does not affect the asymmetric centres of
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Doi:10.1039/c5ra01084e
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