Chemistry Letters p. 677 - 680 (1994)
Update date:2022-08-11
Topics:
Shiina, Isamu
Mukaiyama, Teruaki
An efficient method for the synthesis of macrolides directly from ω-hydroxycarboxylic acids is established by using 4-(trifluoromethyl)benzoic anhydride and a catalytic amount of active titanium(IV) salts together with chlorotrimethylsilane under mild conditions.
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