Tetrahedron Letters p. 6997 - 7000 (1997)
Update date:2022-08-30
Topics:
Brook, Michael A.
Gottardo, Christine
Balduzzi, Sonya
Mohamed, Mustafa
The use of the tris(trimethylsilyl)silyl (sisyl) group as a photolabile protecting group for primary and secondary alcohols was demonstrated. Sisyl ethers of a number of alcohols (yields 70-97%) were stable to many synthetic protocols, but could be deprotected using photolysis to give the starting alcohols (yields 62-95%).
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