A novel approach to the synthesis of symmetric optically active 2,5-dioxopiperazines

Article abstract of DOI:10.1055/s-1992-26131

'Gas-solid-phase' method for the preparation of some cyclic dipeptides,2,5-dioxopiperazines (diketopiperazines), is described. The method implies cyclodimerization of vaporous aliphatic α-amino acids in the presence of silica at reduced pressure and yields optically active 2,5-dioxopiperazines.