Convenient preparative method of α,β-disubstituted cyclopentenone by zirconium promoted intermolecular coupling of an alkyne, EtMgBr (or ethylene) and CO

DOI: 10.1016/S0040-4020(97)00612-1

Source and publish data:

Tetrahedron p. 9123 - 9134 (1997)

Update date:2022-08-05

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Authors:

Takahashi, Tamotsu

Xi, Zhenfeng

Nishihara, Yasushi

Huo, Shouquan

Kasai, Kayoko

Aoyagi, Koichiro

Denisov, Victor

Negishi, Ei-Ichi

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Article abstract of DOI:10.1016/S0040-4020(97)00612-1

Treatment of Cp2ZrCl₂ with 2 equiv of EtMgBr in THF, followed by addition of an internal alkyne and subsequent treatment with CO/I₂ gave α,β-disubstituted cyclopentenone in good to high yields. When a conjugated enyne was used as an

Full text of DOI:10.1016/S0040-4020(97)00612-1

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