Preparation of oligodeoxynucleotides containing 6-methylthiopurine residues by chemical synthesis or specific methylation

Article abstract of DOI:10.1080/15257779508012504

Two methods (chemical synthesis and specific methylation) are described for the preparation of oligodeoxynucleotides containing 6-methylthiopurine residues. 6-Methylthiopurine phosphoramidite (6) is prepared and incorporated into oligomers. Methylation with methyl iodide of 6-thiopurine (or 6-thioguanine) in oligonucleotides also leads to exclusive production of 6-methylthiopurine (or 6-methylthioguanine) oligomers.

Full text of DOI:10.1080/15257779508012504

This article was downloaded by: [Michigan State University]
On: 14 January 2015, At: 13:26
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Preparation of Oligodeoxynucleotides
Containing 6-Methylthiopurine Residues
by Chemical Synthesis or Specific
Methylation
Yao-Zhong Xu a , Qinguo Zheng a & Peter F. Swann a
a Cancer Research Campaign Nitrosamine-Induced Cancer Research
Group Department of Biochemistry and Molecular Biology ,
University College London Gower Street , London, WC1E 6BT,
England
Published online: 16 Feb 2007.
To cite this article: Yao-Zhong Xu , Qinguo Zheng & Peter F. Swann (1995) Preparation of
Oligodeoxynucleotides Containing 6-Methylthiopurine Residues by Chemical Synthesis or Specific
Methylation, Nucleosides and Nucleotides, 14:3-5, 929-933
To link to this article: http://dx.doi.org/10.1080/15257779508012504
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &
Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions