SYNTHESIS OF TWO RIGID DIACYLGLYCEROL ANALOGUES HAVING A PERHYDRO FUROFURAN BIS-γ-BUTYROLACTONE SKELETON. 3.

DOI: 10.1016/S0040-4039(00)79338-5

Source and publish data:

Tetrahedron Letters p. 4317 - 4320 (1993)

Update date:2022-08-17

Topics:

Authors:

Lee, Jeewoo

Marquez, Victor E.

Bahador, Afshin

Kazanietz, Marcelo G.

Blumberg, Peter M.

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Article abstract of DOI:10.1016/S0040-4039(00)79338-5

The stereoselective synthesis of two new bis-γ-butyrolactones starting from 1,2:5,6-di-O-isopropylidene-α-D-allofuranose was completed in 22 steps.One of the isomers (3a) showed very good binding affinity towards protein kinase C.

Full text of DOI:10.1016/S0040-4039(00)79338-5

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