Tetrahedron Letters p. 1853 - 1856 (1998)
Update date:2022-08-11
Topics:
Schultze, Lisa M.
Chapman, Harlan H.
Dubree, Nathan J. P.
Jones, Robert J.
Kent, Kenneth M.
Lee, Thomas T.
Louie, Michael S.
Postich, Michael J.
Prisbe, Ernest J.
Rohloff, John C.
Yu, Richard H.
The anti-HIV nucleotide analogue PMPA can be prepared on a kilogram-scale by a three step sequence: i) condensation of adenine with (R)-propylene carbonate, ii) alkylation of the resulting (R)-9- (2-hydroxypropyl)adenine with diethyl p- toluenesulfonyloxymethanephosphonate using lithium tert-butoxide and iii) cleavage of the phosphonate ester functionalities with bromotrimethylsilane.
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