Synthesis of carboxylic acids through the formation of C-C bond between saturated hydrocarbons and CO in the presence of Mg/K2S2O8/TFA system

Article abstract of DOI:10.1246/cl.1999.449

Magnesium powder (Mg) promoted the carboxylation reaction of saturated hydrocarbons with carbon monoxide (CO) in the presence of potassium peroxodisulfate (K₂S₂O₈) in trifluoroacetic acid (TFA) to yield the corresponding carboxylic acids and alkyl trifluoroacetates. About 80% conversion of cyclohexane was achieved when 5 mmol of magnesium, 5 mmol of potassium peroxodisulfate, 3 mL of TFA, 1 mmol of cyclohexane, 50 atm of CO were used at 80 °C for 30 h.