Stereoselective Synthesis of β-Phenylserine from Glycine and Benzaldehyde as Mediated by Catalytic Bilayer Membranes, Artificial Vitamin B6-dependent Enzymes

Article abstract of DOI:10.1246/cl.1993.553

The aldolation of glycine with benzaldehyde to yield β-phenylserine was catalyzed by supramolecular assemblies formed with a synthetic peptide lipid, a hydrophobic vitamin B6 derivative, and zinc(II) ions in aqueous media under mild conditions.A diastereomeric ratio of the reaction products was much dependent on a size and a phase property of the vesicular catalyst.