Total Syntheses of Sandalwood Fragrances: (Z)- and (E)-β-Santalol and Their Enantiomers, ent-β-Santalene

Article abstract of DOI:10.1016/S0957-4166(00)80544-3

Via asymmetric Diels-Alder reactions, large scale preparations of enantiomerically pure norbornane-2-carboxylic acids were carried out.Oxidative degradation furnished 2-norbornanone and 3-methyl-2-norbornanone which gave the title compounds via stereoselective alkylations, subsequent Wittig reactions and reductions.