Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor

DOI: 10.1016/j.ejmech.2014.04.066

Source and publish data:

European Journal of Medicinal Chemistry p. 428 - 438 (2014)

Update date:2022-08-11

Topics:

Authors:

Jun, Kyu-Yeon

Kwon, Hanbyeol

Park, So-Eun

Lee, Eunyoung

Karki, Radha

Thapa, Pritam

Lee, Jun-Ho

Lee, Eung-Seok

Kwon, Youngjoo

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Article abstract of DOI:10.1016/j.ejmech.2014.04.066

We describe our rationale for designing specific catalytic inhibitors of topoisomerase II (topo II) over topoisomerase I (topo I). Based on 3D-QSAR studies of previously published dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives, 9 novel dihydroxyl

Full text of DOI:10.1016/j.ejmech.2014.04.066

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