Journal of the American Chemical Society p. 3508 - 3509 (2002)
Update date:2022-08-10
Topics:
Lin, Chun-Cheng
Yeh, Yi-Chun
Yang, Chan-Yi
Chen, Chan-Long
Chen, Gee-Fong
Chen, Chia-Chun
Wu, Yi-Chun
The synthesis, characterization and biological application of mannose encapsulated gold nanoparticles (m-AuNP) are reported. m-AuNP is well dispersed and very stable without aggregation in the media of broad ion strength and pH ranges. The selective binding of m-AuNP to the mannose adhesin FimH of bacterial type 1 pili is demonstrated using transmission electron microscopy. The competition assay with free mannose suggests that m-AuNP binds FimH better than free mannose does. This work demonstrates that carbohydrate attached nanoparticles can be used as an efficient affinity label and a multi-ligand carrier in a biological system. Copyright
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