Synthesis of N-Boc-α-Amino Acids with Nucleobase Residues as Building Blocks for the Preparation of Chiral PNA (Peptidic Nucleic Acids).

Article abstract of DOI:10.1016/0040-4039(95)00052-E

N-Boc-Glutamic acid α-benzyl ester was transformed into 4-bromo-2-(tert-butoxycarbonylamino)-butyric acid benzyl ester using the Barton-Crich protocol.This bromo derivative undergoes nucleophilic substitution with nucleobases to give optically active N-Bo