A facile one-pot cyanation of primary and secondary alcohols. Application of some new Mitsunobu reagents

DOI: 10.1016/S0040-4039(99)01509-9

Source and publish data:

Tetrahedron Letters p. 7355 - 7358 (1999)

Update date:2022-08-11

Topics:

Authors:

Tsunoda, Tetsuto

Uemoto, Kaori

Nagino, Chisato

Kawamura, Megumi

Kaku, Hiroto

Ito, Sho

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Article abstract of DOI:10.1016/S0040-4039(99)01509-9

Some new Mitsunobu reagents, especially N,N,N',N'-tetramethylazodicarboxamide(TMAD)-tributylphosphine (TBP) and cyanomethylenetrimethylphosphorane (CMMP), mediated the direct transformation of primary and secondary alcohols into the corresponding nitriles in the presence of acetone cyanohydrin. This type of cyanation process can convert 3β-cholestanol to 3α-cyanocholestane in high yield with complete Walden inversion.

Full text of DOI:10.1016/S0040-4039(99)01509-9

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