ChemComm
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COMMUNICATION
DOI: 10.1039/C4CC07960D
active PtII species upon NIR light excitation. More studies are
needed to evaluate thoroughly the effect of the excitation power
over cellular environments and to improve the efficacy of
UCNPs as phototriggers by increasing their upconversion yield
and optimize surface functionalization. However, activating
PtIV precursors of anticancer agents, such as cisplatin,
carboplatin or oxaliplatin, with NIR light is indeed an attractive
prospect as these PtIV complexes have extensively been studied
in the last years and some of them have even reached clinical
trials (e.g. iproplatin).20 In particular, the low toxicity (both in
vitro and in vivo) of UCNPs with respect to other nanomaterials
and their multimodal imaging capability are key advantages to
exploit for novel applications in nanomedicine.
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Footnotes should appear here. These might include comments
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