Isoflavanones from the heartwood of Swartzia polyphylla and their antibacterial activity against cariogenic bacteria

Article abstract of DOI:10.1248/cpb.40.2970

The methanolic extract of Swartzia polyphylla DC. heartwood had antibacterial activity against cariogenic bacteria, the mutans Streptococci. The chromatographic purification of the extract afforded seven flavonoids. Among them, three known isoflavanones, dihydrobiochanin A, ferreirin and darbergioidin, and one new isoflavanone, 5,2',4'-trihydroxy-7-methoxyisoflavanone (dihydrocajanin) had potent antibacterial activity against cariogenic bacteria. This effect was not detected on isoflavone derivatives. A comparative antibacterial study of various flavonoids was further performed, and their structure-activity relationship was discussed.

Full text of DOI:10.1248/cpb.40.2970

NII-Electronic Library Service

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NII-Electronic Library Service

NII-Electronic Library Service