Digitalis-like compounds: Synthesis and biological evaluation of 3β-(aminoalkylthio) derivatives

DOI: 10.1016/S0960-894X(97)00039-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 469 - 472 (1997)

Update date:2022-08-30

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Authors:

Gobbini, Mauro

Benicchio, Alessandra

Padoani, Gloria

Torri, Marco

Melloni, Piero

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Article abstract of DOI:10.1016/S0960-894X(97)00039-5

The synthesis and the binding affinities to the digitalis receptor on the Na⁺, K⁺-ATPase of a series of 3β-(aminoalkylthio digitalis derivatives are described. In most cases these derivatives showed a higher binding affinity than that of the corresponding 3β-hydroxy and 3β-mercapto parent compounds.

Full text of DOI:10.1016/S0960-894X(97)00039-5

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