Digitalis-like compounds: Synthesis and biological evaluation of 3β-(aminoalkylthio) derivatives

Article abstract of DOI:10.1016/S0960-894X(97)00039-5

The synthesis and the binding affinities to the digitalis receptor on the Na⁺, K⁺-ATPase of a series of 3β-(aminoalkylthio digitalis derivatives are described. In most cases these derivatives showed a higher binding affinity than that of the corresponding 3β-hydroxy and 3β-mercapto parent compounds.