Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines

DOI: 10.1021/jm00397a029

Source and publish data:

Journal of Medicinal Chemistry p. 433 - 444 (1988)

Update date:2022-08-10

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Authors:

Grunewald

Sall Sall

Monn Monn

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Article abstract of DOI:10.1021/jm00397a029

Compounds of the benzylamine (BA) class are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28). Restriction of the aminomethyl side chain through its incorporation into a cyclic framework as in 1,2,3,4-tetrahydroisoquinoline (

Full text of DOI:10.1021/jm00397a029

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