S-(+)-5-(Phenylthio)-2-pentanol and S-(+)-4-(Phenylthio)-2-butanol: Readily Prepared, Useful Additions to the Chirality Pool. Highly Enantioselective Syntheses of Naturally Occurring Spiroketal Pheromones

Article abstract of DOI:10.1021/jo00112a025

The new chirons (S)-4-(phenylthio)-2-butanol (4) and (S)-5-(phenylthio)-2-pentanol (3) have been prepared efficiently in high enantiomeric excess by enzymatic reduction of the corresponding readily available ketones.Using the latter as a chiral building b