Utilization of Basic Alumina in a One-Pot Synthesis of 1,4-Diketones, 1,4,7-Triketones, and Dihydrojasmone by Conjugate Addition of Nitroalkanes to Enones

Article abstract of DOI:10.1055/s-1988-27524

The one-pot synthesis of functionalized 1,4-diketones was achieved in good yields by conjugate addition of primary nitroalkanes to α,β-unsaturated carbonyl compounds on basic alumina without solvent, followed by in situ oxidation with 30percent aqueous hydrogen peroxide in methanol.The one-pot syntheses of 1,4,7-triketones and dihydrojasmone are also reported.